Fisher’s method revisited: set-based genetic association and interaction studies
Lei Sun · Dec 1, 2017
Date: 2017-12-01 Time: 15:30-16:30 Location: BURN 1205 Abstract: Fisher’s method, also known as Fisher’s combined probability test, is commonly used in meta-analyses to combine p-values from the same test applied to K independent samples to evaluate a common null hypothesis. Here we propose to use it to combine p-values from different tests applied to the same sample in two settings: when jointly analyzing multiple genetic variants in set-based genetic association studies, or when jointly capturing main and interaction effects in the presence of missing one of the interacting variables.